Mai Hoang

hmai@chalmers.se

Introduction
March 2015 – Present, Chalmers University of Technology, Gothenburg, Sweden PhD student September 2010 – November 2011, Umeå University, Umeå, Sweden Master Degree in Chemistry Research study: In vitro model of a-synuclein aggregation and the nature of ex vivo amyloid deposits from Alzheimer’s brain October 2006 – June 2010, Umeå University, Umeå, Sweden Bachelor Degree in Chemistry Period: 2006 – 2009, University of Sciences, Ho Chi Minh city, Vietnam 2009 – 2010, Umeå University, Umeå, Sweden Research study: Autoimmune responses to a-synuclein and its amyloids in Parkinson’s disease

Research
Develop nanobio chemical imaging methodology for direct observation of Drosophila brain with 10~50 nm spatial resolution using innovative nanoscopic tools such as NanoSIMS, ToF-SIMS. Developing sample preparation protocols that allow multimodal imaging of Drosophila brain tissue with both ToF-SIMS and NanoSIMS to image and analyze the biological and chemical distributions of the samples. Ideally, sample preparation should preserve the structural, biological, and chemical distributions of the samples. Rapid fixation either by freezing or chemical fixation is needed to prevent loss and redistribution of compounds of interest. Using aqueous chemical fixation and resin embedding to maintain tissue morphology produces samples that are suitable for analysis with both SIMS techniques. Study the changes in lipid structure and chemical distribution of Drosophila brain after cocaine treatment and then observe the brain recovery itself after stopping using cocaine. Understand the behavioral and neurological effect of cocaine in Drosophila brain which may model these processes occurring in cocaine-addicted humans.